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QC Ware Demonstrates Hybrid Quantum-Classical Chemistry Workflow with IBM Quantum Hardware

Mohib Ur Rehman
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⚡ Quantum Brief
QC Ware has demonstrated a hybrid quantum-classical workflow for computational chemistry, using its Promethium platform alongside IBM’s 156-qubit Heron superconducting quantum processor. The team calculated the electrostatic interaction energy of nitric oxide reductase, a complex metalloenzyme, by integrating GPU-accelerated molecular modeling and classical methods with quantum measurements. This proof-of-concept, led by Dr. Kin-Joe Sham, showcases how Promethium can extend classical chemistry capabilities while laying groundwork for future hybrid applications. The workflow targets a key molecular property critical to drug discovery and materials science, though it remains a technology demonstration rather than a fully deployed product feature.
Why it matters

This hybrid approach bridges classical and quantum computing to tackle complex molecular systems, accelerating research in catalysis and drug design while revealing current hardware limitations in scalability and integration.

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QC Ware Demonstrates Hybrid Quantum-Classical Chemistry Workflow with IBM Quantum Hardware

Insider BriefPress release – QC Ware (“QC Ware” or the “Company”) today announced a technology demonstration of a hybrid quantum-classical computational chemistry workflow using Promethium® and IBM Quantum hardware.The demonstration calculated electrostatic interaction energy for nitric oxide reductase by combining GPU-accelerated molecular modeling and classical chemistry methods with quantum measurements performed on IBM’s 156-qubit Heron superconducting quantum processor. The work highlights how Promethium can be used alongside quantum hardware in scientifically relevant workflows. This was a technology demonstration and is not currently a fully integrated Promethium product capability.“This demonstration shows how classical and quantum computing can be combined to address meaningful computational chemistry problems,” said Dr. Kin-Joe Sham, Co-Founder and COO at QC Ware. “We believe Promethium delivers high-performance computational chemistry today while providing a foundation for exploring future hybrid workflows.”Nitric oxide reductase is a chemically complex metalloenzyme system, making it a relevant benchmark for evaluating advanced computational methods. The workflow focused on electrostatic interaction energy, an important molecular property in drug discovery, catalysis, and materials science.The demonstration builds on QC Ware‘s previously published research in hybrid quantum-classical chemistry and reflects the Company’s broader strategy of delivering practical, GPU-accelerated quantum chemistry today while advancing the use of artificial intelligence and quantum computing to address increasingly challenging scientific problems.Available today, Promethium’s GPU-native architecture enables researchers to apply quantum chemistry across larger molecular systems and more compounds than has traditionally been practical. For selected workloads, Promethium runs demanding calculations up to 20× faster than the main conventional platforms, helping researchers generate molecular-level insights in hours instead of weeks and accelerating decision-making across drug discovery, catalysis, and materials science.TopicsShare Get the latest research, company news, and market intelligence every week. MENTIONED IN THE ARTICLEQC Ware provides enterprise applications for quantum computers.More in Research The Quantum Insider (TQI) is the leading source for the latest quantum technology news, market intelligence, industry analysis, and data covering the global quantum ecosystem.NEWSROOMPLATFORMSERVICESCOMPANY© 2026 Resonance Alliance Inc. All rights reserved.A RESONANCE NETWORK PROPERTYOne of our team will be in touch to learn more about your requirements, and provide pricing and access options.Subscribe to our industry leading leading newsletter for the latest in quantum news and insights. Necessary cookies are always on to ensure the website works. Optional cookies help us understand how the site is used. Privacy Policy

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Source: Quantum Insider

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