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PepGen Inc. (PEPG) Discusses Topline Results From Lowest Dose MAD Cohort in Phase II FREEDOM2 Study With Favorable Safety, Splicing and vHOT Data Transcript

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PepGen announced positive topline results from the lowest-dose cohort of its Phase II FREEDOM2 study for PGN-EDODM1, a Duchenne muscular dystrophy treatment, showing favorable safety and efficacy signals. The study’s multiple ascending dose (MAD) cohort demonstrated successful exon skipping and splicing activity, a key mechanism for restoring dystrophin production in patients. Voluntary functional tests (vHOT) indicated early signs of motor function improvement, aligning with the drug’s targeted therapeutic goals for Duchenne patients. Management highlighted plans to advance higher-dose cohorts and release additional data later in 2026, pending regulatory feedback and trial progression. Analysts on the call emphasized the potential clinical impact, with questions focusing on long-term safety, dosing optimization, and next-phase trial design.
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SA Transcripts159.16K FollowersFollow5ShareSaveCommentsPlay Earnings CallPlay Earnings Call PepGen Inc. (PEPG) Discusses Topline Results From Lowest Dose MAD Cohort in Phase II FREEDOM2 Study With Favorable Safety, Splicing and vHOT Data March 30, 2026 4:30 PM EDT Company Participants James McArthur - President, CEO, Treasurer, Secretary & DirectorPaul Streck - Executive VP and Head of Research & Development Conference Call Participants Laurence WattsKonstantinos Biliouris - Oppenheimer & Co. Inc., Research DivisionJoseph Schwartz - Leerink Partners LLC, Research DivisionPaul Matteis - Stifel, Nicolaus & Company, Incorporated, Research DivisionLaura Chico - Wedbush Securities Inc., Research DivisionDebjit Chattopadhyay - Guggenheim Securities, LLC, Research DivisionAnanda Ghosh - H.C. Wainwright & Co, LLC, Research Division Presentation Operator Welcome to the PepGen conference call to discuss top line results from lowest dose MAD cohort in the Phase II FREEDOM2 study, demonstrating promising safety, splicing and vHOT data. [Operator Instructions] As a reminder, this call is being recorded today, Monday, March 30, 2026. I would now like to hand the conference call over to Laurence Watts of New Street Investor Relations. Please go ahead.

Laurence Watts Thank you, operator. Joining us on the call today from PepGen are President and Chief Executive Officer, James McArthur; Executive Vice President, Head of Research and Development, Paul Streck; and Chief Financial Officer, Noel Donnelly. During this call, management will make forward-looking statements, including statements related to its Phase II trial of PGN-EDODM1 as well as the timing of additional or future data from the studies and the company's development plans. Our actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of risks and uncertainties. Factors that could cause these results to be different from these statements include factors the company describes in its securities filings, including its annual report on Form 10-K and our quarterly reports on Form 10-Q. PepGen

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