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Otsuka Holdings Co., Ltd. (OTSKY) M&A Call Prepared Remarks Transcript

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⚡ Quantum Brief
Otsuka Holdings completed a $700 million upfront acquisition of Transcend Therapeutics, a New York-listed biotech firm specializing in rapid-acting psychiatric treatments, pending regulatory approval. The deal includes potential milestone payments up to $525 million tied to future product sales, with Otsuka America securing full ownership of Transcend’s pipeline, including TSND-201. Transcend’s leadership includes CEO Blake Mandell and Yale psychiatrist Dr. Benjamin Kelmendi, whose research focuses on ketamine, psilocybin, and neurocircuitry mechanisms behind rapid-acting antidepressants. TSND-201, a key asset, is advancing through Phase III trials as a prodrug for depression, with clinical data emphasizing both efficacy and underlying neural pathways. Otsuka’s move aligns with its strategic push into novel neurotherapeutics, leveraging Transcend’s expertise in psychedelic-derived treatments and rapid-response psychiatric interventions.
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SA Transcripts159.25K FollowersFollow5ShareSaveCommentsPlay Earnings CallPlay Earnings Call Otsuka Holdings Co., Ltd. (OTSKY) M&A Call April 9, 2026 8:00 PM EDT Company Participants Conference Call Participants Takeshi Watanabe Presentation Takeshi Watanabe Good morning. I'm Watanabe. Nice to meet you. So let me start. Today, in the first half, I'd like to talk about acquisitions and how it happened, the introduction of the company we acquired and also our strategic intent. In the second half, we will talk about TSND-201, the characteristics, clinical data and the characteristics.

So Transcend Therapeutics company, it's a company listed in New York. And the company has this product, the rapid-acting treatment products. And this is the company to develop the rapid-acting treatment product. And now our process for acquisition is completed, and we are waiting for the clearance by the authority. And Otsuka subsidiary, Otsuka America, Inc. will have another company to acquire 100% of the stakes of the company. And USD 700 million will be upfront payments. In addition to that, we will have the conditional milestones payments with the sales of the products up to the USD 525 million when the product was sold as we speak. And then Kevin is one of the founders and he's venture capitalist.

And Blake Mandell is one of the co-founder and is the CEO today. And Dr. Benjamin Kelmendi is the psychiatrist from Yale University. And Dr. Benjamin is working on the ketamine and TSND-201. He works on that plus psilocybin, ketamine, psilocybin, 201, and he drove to get clinical data, not just the efficacy. Why it happened the neuro circuits platforms. Those are the areas of his basic research. And now it is working -- we are working on the Phase III TSND-201 study and labeling products, prodrug for TSND-201, those 2 substances they own. And I'd like to give you

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