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Hydrogels find their inner magnetism

Stephen J. Blundell
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Researchers discovered unexpected paramagnetism in calcium-alginate hydrogels, where carbonyl (C=O) groups interacting with calcium ions generate strong magnetic responses previously unseen in non-metallic soft materials. The effect, documented in Nature Materials (April 2026), challenges conventional wisdom by demonstrating paramagnetism in biocompatible hydrogels—traditionally non-magnetic—via electron spin alignment induced by calcium cations. Potential biomedical applications include MRI contrast agents, drug delivery systems, and magnetic field-responsive implants, leveraging the material’s non-toxicity and tunable magnetic properties for precision medicine. The study builds on Heisenberg’s 1928 spin-exchange theories but applies them to soft matter, bridging quantum physics and materials science to create magnetism without rare-earth metals or external doping. Lead author Ruoyang Chen’s team at Shanghai’s Fudan University suggests this mechanism could enable "smart" hydrogels for diagnostics, though clinical translation requires further stability and scalability testing.
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Subjects Magnetic materialsMagnetic properties and materials Hydrogels containing C=O groups and calcium cations show an unexpected paramagnetic effect that may have biomedical applications. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution Access options Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Rent or buy this article Prices vary by article type from$1.95 to$39.95 Learn more Prices may be subject to local taxes which are calculated during checkout Fig. 1: Calcium ions interacting with the carbonyl group on calcium alginate. ReferencesKhan, S., Ullah, A., Ullah, K. & Rehman, N. Des. Monomers Polym. 19, 456–478 (2016).Article CAS Google Scholar Wichterie, O. & Lim, D. Nature 185, 117–118 (1960).Article Google Scholar Lim, F. & Sun, A. M. Science 210, 908–910 (1980).Article CAS PubMed Google Scholar Green, J. J. & Elisseeff, J. H. Nature 540, 386–394 (2016).Article CAS PubMed PubMed Central Google Scholar Heisenberg, W. Z. Phys. 49, 619–636 (1928).CAS Google Scholar Tamura, M. et al. Chem. Phys. Lett. 186, 401–404 (1991).Article CAS Google Scholar Blundell, S. J. & Pratt, F. L. J. Phys. Condens. Matter 16, R771–R828 (2004).Article CAS Google Scholar Londhe, P. V. et al. Coord. Chem. Rev. 522, 216228 (2025).Article CAS Google Scholar Chen, R. et al. Nat. Mater. https://doi.org/10.1038/s41563-025-02477-3 (2026).Article PubMed Google Scholar Wahsner, J., Gale, E. M., Rodríguez-Rodríguez, A. & Caravan, P. Chem. Rev. 119, 957–1057 (2019).Article CAS PubMed Google Scholar Download referencesAuthor informationAuthors and AffiliationsDepartment of Physics, University of Oxford, Oxford, UKStephen J. BlundellAuthorsStephen J. BlundellView author publicationsSearch author on:PubMed Google ScholarCorresponding authorCorrespondence to Stephen J. Blundell.Ethics declarations Competing interests The author declares no competing interests. Rights and permissionsReprints and permissionsAbout this articleCite this articleBlundell, S.J. Hydrogels find their inner magnetism. Nat. Mater. (2026). https://doi.org/10.1038/s41563-026-02572-zDownload citationPublished: 03 April 2026Version of record: 03 April 2026DOI: https://doi.org/10.1038/s41563-026-02572-zShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy shareable link to clipboard Provided by the Springer Nature SharedIt content-sharing initiative Unexpected strong paramagnetism of hydrogels containing carbon–oxygen double bonds induced by calcium cations Ruoyang ChenYue-Yu ZhangHaiping Fang Nature Materials Article 28 Jan 2026

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