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GRAIL, Inc. (GRAL) Q4 2025 Earnings Call Transcript

Seeking Alpha

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GRAIL reported Q4 2025 earnings on February 19, 2026, highlighting strong revenue growth driven by its multi-cancer early detection (MCED) blood test, Galleri, which expanded commercial adoption in the U.S. and Europe. CEO Robert Ragusa emphasized Galleri’s clinical validation, citing new real-world data showing 76% sensitivity in detecting 50+ cancers, reinforcing its potential to transform early cancer screening. CFO Aaron Freidin projected 2026 revenue of $1.2–$1.4 billion, up 40% YoY, fueled by payer coverage expansions and direct-to-consumer sales, though margins remain pressured by R&D investments. Chief Scientific Officer Harpal Kumar announced partnerships with NHS England and Japan’s health ministry to pilot Galleri in national screening programs, marking its first large-scale public health integrations. Analysts questioned scaling challenges, but leadership reaffirmed confidence in Galleri’s long-term viability, targeting FDA approval for additional cancer types by late 2026.

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SA Transcripts158.51K FollowersFollow5ShareSaveComment(1)Play Earnings CallPlay Earnings Call GRAIL, Inc. (GRAL) Q4 2025 Earnings Call February 19, 2026 5:00 PM EST Company Participants Robert Ragusa - CEO & DirectorHarpal Kumar - Chief Scientific Officer & President InternationalJoshua Ofman - PresidentAaron Freidin - Chief Financial OfficerAndrew Partridge - Chief Commercial Officer Conference Call Participants Subhalaxmi Nambi - Guggenheim Securities, LLC, Research DivisionKyle Mikson - Canaccord Genuity Corp., Research DivisionDouglas Schenkel - Wolfe Research, LLCCatherine Ramsey - Robert W. Baird & Co. Incorporated, Research DivisionDaniel Brennan - TD Cowen, Research Division Presentation Operator Good day, ladies and gentlemen, and welcome to the GRAIL Fourth Quarter 2025 Earnings Call. [Operator Instructions] Please be advised that this conference call is being recorded. GRAIL Investor Relations, please begin.

Unknown Executive Thank you, operator, and thank you all for joining us today. On the call are Bob Ragusa, our Chief Executive Officer; Aaron Freidin, our Chief Financial Officer; Josh Ofman, President; Sir Harpal Kumar, Chief Scientific Officer and President, International; and Andy Partridge, Chief Commercial Officer. Before we get underway, I'll remind you that we'll be making forward-looking statements based on current expectations. It's our intent that all statements other than statements of historical fact, including statements regarding our anticipated financial results and commercial activity will be covered by the safe harbor provisions for forward-looking statements under federal securities laws. Forward-looking statements are subject to risks and uncertainties. Actual events or results may differ materially from those projected or discussed. All forward-looking statements are based upon currently available information, and GRAIL assumes no obligation to update these statements. To better understand the risks and uncertainties that could cause actual results to differ, we refer you to the documents that GRAIL files with the SEC, including GRAIL's most recent quarterly report and upcoming annual report. This call will also include a discussion of GAAP results

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